Prazosin is a member of the class of α-adrenergic blockers. It is considered as a peripheral vasodilator antihypertensive agent. Prazosin is a derivative of quinazoline.
Application
Prazosin hydrochloride has been used: • to block the α1adrenergic receptors that mediate sympathetic vasoconstriction in mice • as an α1-adrenoceptor blocker,administered intragastrically in rats • as a vasodilator,administered together with inuslin into the left ventricle of mice for the assessment of its effects on renal functions
Biochem/physiol Actions
Peripheral α1-adrenoceptor antagonist; vasodilator. Prazosin can be used to treat chronic posttraumatic stress disorder (PTSD). It plays a role in reducing blood pressure by relaxing blood vessels, hence used in the treatment of high blood pressure.