PRKACA 抗体（pThr196 + pThr198）：偶

产品名称：PRKACA 抗体（pThr196 + pThr198）：偶联Streptavidin-PRKACA Antibody (pThr196 + pThr198): Streptavidin

产品货号：SPC-1066D-STR

产品规格：100ul

应用类型：WB | AM

保存建议：PRKACA 抗体（pThr196 + pThr198）：偶联Streptavidin-PRKACA Antibody (pThr196 + pThr198): Streptavidin厂家推荐蓝冰运输。收到产品后建议保存于-20ºC。

背景资料：Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA, TRPC1 and VASP. RORA is activated by phosphorylation. Required for glucose-mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the regulation of platelets in response to thrombin and collagen; maintains circulating platelets in a resting state by phosphorylating proteins in numerous platelet inhibitory pathways when in complex with NF-kappa-B (NFKB1 and NFKB2) and I-kappa-B-alpha (NFKBIA), but thrombin and collagen disrupt these complexes and free active PRKACA stimulates platelets and leads to platelet aggregation by phosphorylating VASP. Prevents the antiproliferative and anti-invasive effects of alpha-difluoromethylornithine in breast cancer cells when activated. RYR2 channel activity is potentiated by phosphorylation in presence of luminal Ca2+, leading to reduced amplitude and increased frequency of store overload-induced Ca2+ release (SOICR) characterized by an increased rate of Ca2+ release and propagation velocity of spontaneous Ca2+ waves, despite reduced wave amplitude and resting cytosolic Ca2+. TRPC1 activation by phosphorylation promotes Ca2+ influx, essential for the increase in permeability induced by thrombin in confluent endothelial monolayers. PSMC5/RPT6 activation by phosphorylation stimulates proteasome. Regulates negatively tight junction (TJs) in ovarian cancer cells via CLDN3 phosphorylation. NFKB1 phosphorylation promotes NF-kappa-B p50-p50 DNA binding. Involved in embryonic development by down-regulating the Hedgehog (Hh) signaling pathway that determines embryo pattern formation and morphogenesis. Isoform 2 phosphorylates and activates ABL1 in sperm flagellum to promote spermatozoa capacitation. Prevents meiosis resumption in prophase-arrested oocytes via CDC25B inactivation by phosphorylation. May also regulate rapid eye movement (REM) sleep in the pedunculopontine tegmental (PPT). Phosphorylates APOBEC3G and AICDA.

点击：PRKACA 抗体（pThr196 + pThr198）：偶联Streptavidin-PRKACA Antibody (pThr196 + pThr198): Streptavidin查看更详细产品说明，更多应用、储存、价格、货期等信息请致电400-6800-868垂询StressMarq中国区域授权总代理艾美捷科技有限公司。更多特色试剂盒、特色抗体以及特色试剂等产品评论，请点击查看每日生物评论网站。

StressMarq Biosciences Inc. 在2007年成立于加拿大维多利亚，是一家生物科技公司，专门从事试剂与试剂盒研究，服务范围遍及全球50多个国家。 StressMarq公司的核心技术领域为细胞应激（尤其是热休克蛋白（HSP）领域，领先全球），离子通道，载体研究，同时在神经科学领域推出特有的具有生物活性的Tau蛋白与a-突触核蛋白。产品领域涉及到：细胞凋亡、细胞信号、通路和转运、细胞器标志物、热休克、神经生物学、神经科学、氧化应激、磷酸化运输等。除了提供用于进一步研究的相关工具外，StressMarq还提供全新的尖端研究工具，用于开发新的生物项目，包括全球独特的a B晶体蛋白ELISA试剂盒（现在是公认的乳腺癌标志物）；热休克同源蛋白70（Hsc70）ELISA试剂盒；以及用于神经衰退研究的Tau活性蛋白与a-突触核蛋白。本公司已将专业技术扩展到抗体、小分子离子通道与载体等更新领域，前者包括当前热门的核心领域：Nav、Cav、TRP、Kv、KCNQ、HCN，后者包括当前热门的核心领域：ENaC、NCC和NKCC2以及主要水通道蛋白载体。

艾美捷科技有限公司品线覆盖生物研究各个领域，主要包括：分子生物学（核酸蛋白研究工具、cDNA/RNA、转染试剂、植物组培/细胞培养、生化试剂及试剂盒），试剂（蛋白酶抑制剂、化合物、荧光染料/探针、动物血清）、抗体（一抗、二抗、封闭血清）， 蛋白及试剂盒（细胞因子/重组蛋白、细胞凋亡/代谢/损伤、表观遗传、天然免疫）等。艾美捷为您寻找并提供最优的产品解决方案、最完备的物流服务、最及时的售后服务。如果您对上述产品线感兴趣，请致电免费服务热线到艾美捷垂询相关产品信息及完整实验解决方案。

关键词：PRKACA Antibody (pThr196 + pThr198): Streptavidin，PRKACA 抗体（pThr196 + pThr198）：偶联Streptavidin，PRKACA