Anti-ARHGEF11 antibody

Anti-ARHGEF11 antibody

Cat. No.    JC261320
Package    25 μl/100 μl/200 μl
Storage    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Product overview
Description                   Anti-ARHGEF11 rabbit polyclonal antibody
Applications        ELISA, WB, IHC 
Immunogen               Synthetic peptide of human ARHGEF11
Reactivity                 Human, Mouse, Rat
Content                     0.8 mg/ml
Host species               Rabbit
Ig class                  Immunogen-specific rabbit IgG
Purification                 Antigen affinity purification

Target information
Symbol                 ARHGEF11
Full name                 Rho guanine nucleotide exchange factor (GEF) 11
Synonyms    GTRAP48; PDZ-RHOGEF
Swissprot    O15085

Target Background
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. A similar protein in rat interacts with glutamate transporter EAAT4 and modulates its glutamate transport activity. Expression of the rat protein induces the reorganization of the actin cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. Two alternative transcripts encoding different isoforms have been described.

Anti-ARHGEF11 antibody
Applications
Immunohistochemistry
Predicted cell location: Cytoplasm
Positive control: Human gasrtic cancer
Recommended dilution: 25-100    Predicted cell location: Cytoplasm
Positive control: Human thyroid cancer
Recommended dilution: 25-100