Product overview Description Anti-ZNF354A rabbit polyclonal antibody
Applications ELISA, IHC
Immunogen Fusion protein of human ZNF354A
Reactivity Human, Mouse, Rat
Content 0.5 mg/ml
Host species Rabbit
Ig class Immunogen-specific rabbit IgG
Purification Antigen affinity purification
Target information Symbol ZNF354A
Full name zinc finger protein 354A
Synonyms EZNF; HKL1; KID1; KID-1; TCF17; HEL104
Swissprot O60765
Target Background ZNF354A, also called EZNF, KID-1 or TCF17, belongs to the Krüppel C2H2-type zinc-finger family of proteins that contain KRAB domains and act as transcriptional regulators. Expressed primarily in the adult kidney, ZNF354A is a transcriptional repressor that plays a role in late renal development and is suppressed after renal ischemia. The N-terminus of ZNF354A contains the KRAB domain which confers transcriptional repressor activity, while the C-terminus contains multiple Cys2His2-zinc fingers. ZNF354A is located in the nucleolus and is thought to specifically influence development of the proximal tubule by shutting off dispensable or inhibitory genes. Reduced ZNF354A expression prevents proper cell differentiation and may, therefore, be implicated in renal carcinoma.
Applications Immunohistochemistry
Predicted cell location: Nucleus and Cytoplasm
Positive control: Human cervical cancer
Recommended dilution: 30-150 Predicted cell location: Nucleus and Cytoplasm
Positive control: Human tonsil
Recommended dilution: 30-150