Anti-IDO2 antibody

Anti-IDO2 antibody

Cat. No.     JC223764
Package    25 μl/100 μl/200 μl
Storage    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Product overview
Description                   Anti-IDO2 rabbit polyclonal antibody
Applications        ELISA, WB, IHC 
Immunogen               Full length fusion protein
Reactivity                 Human
Content                     1 mg/ml
Host species               Rabbit
Ig class                  Immunogen-specific rabbit IgG
Purification                 Antigen affinity purification

Target information
Symbol                 IDO2
Full name                 indoleamine 2,3-dioxygenase 2
Synonyms    INDOL1
Swissprot    Q6ZQW0

Target Background
INDOL1 is also known as IDO2 (indoleamine 2,3-dioxygenase 2) and is a 407 amino acid protein that is expressed in various tissues, including liver, small intestine, spleen, placenta, thymus, lung, brain, kidney, colon and dendritic cells. INDOL1 is selectively inhibited by D-1MT (1-methyl-d-tryptophan), which also inhibits IDO (indoleamine 2,3-dioxygenase) and is significant because IDO expression causes suppression of T cell responses to tumors in dendritic cells. The inhibition of INDOL1 by D-1MT suggests a common function in immunomodulation. In the human INDOL1 gene, two single nucleotide polymorphisms have been detected which abolish the enzymatic function of INDOL1.

Applications
Immunohistochemistry
Predicted cell location: Cytoplasm
Positive control: Human brain
Recommended dilution: 30-150