Anti-CASP5 antibody

Anti-CASP5 antibody

Cat. No.     JC223710
Package    25 μl/100 μl/200 μl
Storage    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Product overview
Description                   Anti-CASP5 rabbit polyclonal antibody
Applications        ELISA, IHC 
Immunogen               Fusion protein of human CASP5
Reactivity                 Human
Content                     1 mg/ml
Host species               Rabbit
Ig class                  Immunogen-specific rabbit IgG
Purification                 Antigen affinity purification

Target information
Symbol                 CASP5
Full name                 caspase 5, apoptosis-related cysteine peptidase
Synonyms    ICH-3; ICEREL-III; ICE(rel)III
Swissprot    P51878

Target Background
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Overexpression of the active form of this enzyme induces apoptosis in fibroblasts. Max, a central component of the Myc/Max/Mad transcription regulation network important for cell growth, differentiation, and apoptosis, is cleaved by this protein; this process requires Fas-mediated dephosphorylation of Max. The expression of this gene is regulated by interferon-gamma and lipopolysaccharide. Alternatively spliced transcript variants have been identified for this gene.

Applications
Immunohistochemistry
Predicted cell location: Nucleus and Cytoplasm
Positive control: Human colorectal cancer
Recommended dilution: 25-100