Anti-DNMT3L antibody

Anti-DNMT3L antibody

Cat. No.    JC120558        
Package    25 μl/100 μl/200 μl
Storage    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Product overview
Description                   Anti-DNMT3L rabbit polyclonal antibody
Applications        ELISA, IHC 
Immunogen               Fusion protein of human DNMT3L
Reactivity                 Human
Content                     0.4 mg/ml
Host species               Rabbit
Ig class                  Immunogen-specific rabbit IgG
Purification                 Antigen affinity purification

Anti-DNMT3L antibody
Target information
Symbol                 DNMT3L
Full name                 DNA (cytosine-5-)-methyltransferase 3-like
Synonyms    
Swissprot    Q9UJW3

Target Background
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a nuclear protein with similarity to DNA methyltransferases, but is not thought to function as a DNA methyltransferase as it does not contain the amino acid residues necessary for methyltransferase activity. However, it does stimulate de novo methylation by DNA cytosine methyltransferase 3 alpha and is thought to be required for the establishment of maternal genomic imprints. This protein also mediates transcriptional repression through interaction with histone deacetylase 1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Anti-DNMT3L antibody
Applications
Immunohistochemistry
Predicted cell location: Cytoplasm
Positive control: Human colon cancer
Recommended dilution: 10-50    Predicted cell location: Cytoplasm
Positive control: Human thyroid cancer
Recommended dilution: 10-50