γ-球蛋白（牛），9007-83-4，G7516-25G

一般描述

牛丙种球蛋白（BGG）是奶牛和其他牛类免疫系统的重要组成部分。BGG 存在于牛的血液中，主要用于生产疫苗、血清和诊断试剂等医疗制品。BGG 还可用于治疗乙肝等疾病，以及增强人类和其他动物的免疫力。

The γG globulins of bovine serum are categorized by anion exchange chromatography, immunoelectrophoresis, zone electrophoresis, ultracentrifugation, and analysis of the products of papain digestion. They have properties similar to analogous components of human serum. This was determined by the methods such as: gel filtration, immunoelectrophoresis, anion exchange chromatography, ultracentrifugation, and reduction with mercaptoethanol. Fast and slow γG globulins were classified on the basis of differences in electrophoretic migration rates, chromatographic elution positions, and biological activities (complement fixation). Bovine γA was conditionally found in immunoelectrophoretic analyses of serum and chromatographic fractions.

应用

γ-globulin has been used as an immunological challenge in studies of mechanisms of immunotolerance.[1]

Bovine γ-globulins were used to study the constituents and pH changes in protein rich hyaluronan solution affecting the bio-tribological properties of artificial articular joints.[2] It is also used to determine immunoglobulin G in bovine colostrum and milk by direct biosensor SPR-immunoassay.[3]

Bovine γ-globulin was used in rapid screening for monensin residues in poultry plasma by a dry reagent dissociation enhanced lanthanide fluoroimmunoassay.[4] It was also tested for the effects of solution properties on solute and permeate flux in bovine serum albumin-IgG ultrafiltration. [5]

牛γ-球蛋白已被用作免疫耐受机制研究中的一种免疫应激。