Anti-FBXW8 antibody

Anti-FBXW8 antibody

Cat. No.     JC163900
Package    25 μl/100 μl/200 μl
Storage    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Product overview
Description                   Anti-FBXW8 rabbit polyclonal antibody
Applications        ELISA, IHC 
Immunogen               Synthetic peptide of human FBXW8
Reactivity                 Human
Content                     1.92 mg/ml
Host species               Rabbit
Ig class                  Immunogen-specific rabbit IgG
Purification                 Antigen affinity purification

Anti-FBXW8 antibody
Target information
Symbol                 FBXW8
Full name                 F-box and WD repeat domain containing 8
Synonyms    FBW6; FBW8; FBX29; FBXW6; FBXO29
Swissprot    Q8N3Y1

Target Background
This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains a WD-40 domain, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.

Anti-FBXW8 antibody
Applications
Immunohistochemistry
Predicted cell location: Cytoplasm or Nucleus
Positive control: Human esophagus cancer
Recommended dilution: 50-300    Predicted cell location: Cytoplasm or Nucleus
Positive control: Human breast cancer
Recommended dilution: 50-300