Anti-CABLES1 antibody

Anti-CABLES1 antibody

Cat. No.     JC222009
Package    25 μl/100 μl/200 μl
Storage    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Product overview
Description                   Anti-CABLES1 rabbit polyclonal antibody
Applications        ELISA, WB, IHC 
Immunogen               Fusion protein of human CABLES1
Reactivity                 Human, Mouse
Content                     0.4 mg/ml
Host species               Rabbit
Ig class                  Immunogen-specific rabbit IgG
Purification                 Antigen affinity purification

Target information
Symbol                 CABLES1
Full name                 Cdk5 and Abl enzyme substrate 1
Synonyms    CABL1; IK3-1; CABLES; HsT2563
Swissprot    Q8TDN4

Target Background
This gene encodes a protein involved in regulation of the cell cycle through interactions with several cyclin-dependent kinases. One study (PMID: 16177568) reported aberrant splicing of transcripts from this gene which results in removal of the cyclin binding domain only in human cancer cells, and reduction in gene expression was shown in colorectal cancers (PMID: 17982127).Multiple transcript variants encoding different isoforms have been found for this gene.

Applications
Immunohistochemistry
Predicted cell location: Nucleus and Cytoplasm
Positive control: Human prostate cancer
Recommended dilution: 25-100    Predicted cell location: Nucleus and Cytoplasm
Positive control: Human esophagus cancer
Recommended dilution: 25-100