Anti-FBXO32 antibody

Anti-FBXO32 antibody

Cat. No.    JC163697
Package    25 μl/100 μl/200 μl
Storage    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Product overview
Description                   Anti-FBXO32 rabbit polyclonal antibody
Applications        ELISA, IHC 
Immunogen               Synthetic peptide of human FBXO32
Reactivity                 Human, Mouse, Rat
Content                     1.98 mg/ml
Host species               Rabbit
Ig class                  Immunogen-specific rabbit IgG
Purification                 Antigen affinity purification

Anti-FBXO32 antibody
Target information
Symbol                 FBXO32
Full name                 F-box protein 32
Synonyms    Fbx32; MAFbx
Swissprot    Q969P5

Target Background
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and contains an F-box domain. This protein is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. This protein is thus a potential drug target for the treatment of muscle atrophy. Alternative splicing results in multiple transcript variants encoding different isoforms.

Anti-FBXO32 antibody
Applications
Immunohistochemistry
Predicted cell location: Cytoplasm
Positive control: Human liver cancer
Recommended dilution: 30-150    Predicted cell location: Cytoplasm
Positive control: Human prostate cancer
Recommended dilution: 30-150