Anti-IL6ST antibody

Anti-IL6ST antibody

Cat. No.    JC162505    
Package    25 μl/100 μl/200 μl
Storage    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Product overview
Description                   Anti-IL6ST rabbit polyclonal antibody
Applications        ELISA, IHC 
Immunogen               Synthetic peptide of human IL6ST
Reactivity                 Human, Mouse, Rat
Content                     0.3 mg/ml
Host species               Rabbit
Ig class                  Immunogen-specific rabbit IgG
Purification                 Antigen affinity purification

Anti-IL6ST antibody
Target information
Symbol                 IL6ST
Full name                 interleukin 6 signal transducer
Synonyms    CD130; GP130; CDW130; IL-6RB
Swissprot    P40189

Target Background
The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants have been described. A related pseudogene has been identified on chromosome 17.

Anti-IL6ST antibody
Applications
Immunohistochemistry
Predicted cell location: Secreted
Positive control: Human liver cancer
Recommended dilution: 25-100