Anti-ASCC1 antibody

Anti-ASCC1 antibody

Cat. No.     JC221915
Package    25 μl/100 μl/200 μl
Storage    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Product overview
Description                   Anti-ASCC1 rabbit polyclonal antibody
Applications        ELISA, IHC 
Immunogen               Fusion protein of human ASCC1
Reactivity                 Human, Mouse
Content                     0.3 mg/ml
Host species               Rabbit
Ig class                  Immunogen-specific rabbit IgG
Purification                 Antigen affinity purification

Target information
Symbol                 ASCC1
Full name                 activating signal cointegrator 1 complex subunit 1
Synonyms    p50; CGI-18; ASC1p50
Swissprot    Q8N9N2

Target Background
This gene encodes a subunit of the activating signal cointegrator 1 (ASC-1) complex. The ASC-1 complex is a transcriptional coactivator that plays an important role in gene transactivation by multiple transcription factors including activating protein 1 (AP-1), nuclear factor kappa-B (NF-kB) and serum response factor (SRF). The encoded protein contains an N-terminal KH-type RNA-binding motif which is required for AP-1 transactivation by the ASC-1 complex. Mutations in this gene are associated with Barrett esophagus and esophageal adenocarcinoma. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene.

Applications
Immunohistochemistry
Predicted cell location: Cytoplasm
Positive control: Human thyroid cancer
Recommended dilution: 25-100    Predicted cell location: Cytoplasm
Positive control: Human colon cancer
Recommended dilution: 25-100