Anti-CERK antibody

Anti-CERK antibody

Cat. No.     JC221902
Package    25 μl/100 μl/200 μl
Storage    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Product overview
Description                   Anti-CERK rabbit polyclonal antibody
Applications        ELISA, IHC 
Immunogen               Fusion protein of human CERK
Reactivity                 Human, Mouse
Content                     0.4 mg/ml
Host species               Rabbit
Ig class                  Immunogen-specific rabbit IgG
Purification                 Antigen affinity purification

Target information
Symbol                 CERK
Full name                 ceramide kinase
Synonyms    LK4; hCERK; dA59H18.2; dA59H18.3
Swissprot    Q8TCT0

Target Background
CERK converts ceramide to ceramide 1-phosphate (C1P), a sphingolipid metabolite. Both CERK and C1P have been implicated in various cellular processes, including proliferation, apoptosis, phagocytosis, and inflammation. Catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate. Acts efficiently on natural and analog ceramides (C6, C8, C16 ceramides, and C8-dihydroceramide), to a lesser extent on C2-ceramide and C6-dihydroceramide, but not on other lipids, such as various sphingosines. Binds phosphoinositides.

Applications
Immunohistochemistry
Predicted cell location: Cytoplasm
Positive control: Human tonsil
Recommended dilution: 25-100    Predicted cell location: Cytoplasm
Positive control: Human thyroid cancer
Recommended dilution: 25-100