- 询价
- gelatins
- JC221399
- 2025年07月13日
- ELISA, WB
- Rabbit
- 人/动物/植物
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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
上海机纯实业有限公司
- 库存：
大量
- 克隆性：
多克隆
- 保质期：
12个月
- 抗体英文名：
Anti-PPM1D antibody
- 宿主：
Rabbit
- 适应物种：
人/动物/植物
- 应用范围：
ELISA, WB
- 浓度：
1.3 mg/ml
- 保存条件：
-20°C
- 规格：
25 μl/100 μl/200 μl
Cat. No. JC221399
Package 25 μl/100 μl/200 μl
Storage -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Product overview
Description Anti-PPM1D rabbit polyclonal antibody
Applications ELISA, WB, IHC
Immunogen Fusion protein of human PPM1D
Reactivity Human, Mouse
Content 1.3 mg/ml
Host species Rabbit
Ig class Immunogen-specific rabbit IgG
Purification Antigen affinity purification
Target information
Symbol PPM1D
Full name protein phosphatase, Mg2+/Mn2+ dependent 1D
Synonyms WIP1; PP2C-DELTA
Swissprot O15297
Target Background
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development.
Applications
Immunohistochemistry
Predicted cell location: Cytoplasm or Nucleus
Positive control: Human liver cancer
Recommended dilution: 40-200 Predicted cell location: Cytoplasm or Nucleus
Positive control: Human esophagus cancer
Recommended dilution: 40-200
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