Anti-PRKCA antibody

Anti-PRKCA antibody

Cat. No.     JC221138
Package    25 μl/100 μl/200 μl
Storage    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Product overview
Description                   Anti-PRKCA rabbit polyclonal antibody
Applications        ELISA, WB, IHC 
Immunogen               Fusion protein of human PRKCA
Reactivity                 Human, Mouse, Rat
Content                     0.1 mg/ml
Host species               Rabbit
Ig class                  Immunogen-specific rabbit IgG
Purification                 Antigen affinity purification

Target information
Symbol                 PRKCA
Full name                 protein kinase C, alpha
Synonyms    AAG6; PKCA; PRKACA; PKC-alpha
Swissprot    P17252

Target Background
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes.

Applications
Immunohistochemistry
Predicted cell location: Cytoplasm
Positive control: Human liver cancer
Recommended dilution: 25-100    Predicted cell location: Cytoplasm
Positive control: Human lung cancer
Recommended dilution: 25-100