Anti-PAK7 antibody

Anti-PAK7 antibody

Cat. No.     JC221098
Package    25 μl/100 μl/200 μl
Storage    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Product overview
Description                   Anti-PAK7 rabbit polyclonal antibody
Applications        ELISA, WB, IHC 
Immunogen               Fusion protein of human PAK7
Reactivity                 Human, Mouse, Rat
Content                     0.2 mg/ml
Host species               Rabbit
Ig class                  Immunogen-specific rabbit IgG
Purification                 Antigen affinity purification

Target information
Symbol                 PAK7
Full name                 p21 protein (Cdc42/Rac)-activated kinase 7
Synonyms    PAK5
Swissprot    Q9P286

Target Background
The protein encoded by this gene is a member of the PAK family of Ser/Thr protein kinases. PAK family members are known to be effectors of Rac/Cdc42 GTPases, which have been implicated in the regulation of cytoskeletal dynamics, proliferation, and cell survival signaling. This kinase contains a CDC42/Rac1 interactive binding (CRIB) motif, and has been shown to bind CDC42 in the presence of GTP. This kinase is predominantly expressed in brain. It is capable of promoting neurite outgrowth, and thus may play a role in neurite development. This kinase is associated with microtubule networks and induces microtubule stabilization. The subcellular localization of this kinase is tightly regulated during cell cycle progression. Alternatively spliced transcript variants encoding the same protein have been described.

Applications
Immunohistochemistry
Predicted cell location: Cytoplasm, Nucleus
Positive control: Human ovarian cancer
Recommended dilution: 15-50    Predicted cell location: Cytoplasm, Nucleus
Positive control: Human lung cancer
Recommended dilution: 15-50