Anti-LEF1 antibody

Anti-LEF1 antibody

Cat. No.     JC220919
Package    25 μl/100 μl/200 μl
Storage    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Product overview
Description                   Anti-LEF1 rabbit polyclonal antibody
Applications        ELISA, IHC 
Immunogen               Fusion protein of human LEF1
Reactivity                 Human, Mouse, Rat
Content                     0.4 mg/ml
Host species               Rabbit
Ig class                  Immunogen-specific rabbit IgG
Purification                 Antigen affinity purification

Target information
Symbol                 LEF1
Full name                 lymphoid enhancer-binding factor 1
Synonyms    LEF-1; TCF10; TCF7L3; TCF1ALPHA
Swissprot    Q9UJU2

Target Background
This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. This transcription factor is involved in the Wnt signaling pathway, and it may function in hair cell differentiation and follicle morphogenesis. Mutations in this gene have been found in somatic sebaceous tumors. This gene has also been linked to other cancers, including androgen-independent prostate cancer. Alternative splicing results in multiple transcript variants.

Applications
Immunohistochemistry
Predicted cell location: Nucleus and Cytoplasm
Positive control: Human cervical cancer
Recommended dilution: 25-100    Predicted cell location: Nucleus and Cytoplasm
Positive control: Human tonsil
Recommended dilution: 25-100