Anti-ZNF143 antibody

Anti-ZNF143 antibody


Cat. No.     JK163141
Package    25 μl/100 μl/200 μl
Storage    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Product overview
Description                   Anti-ZNF143 rabbit polyclonal antibody
Applications        ELISA, IHC 
Immunogen               Synthetic peptide of human ZNF143
Reactivity                 Human, Mouse, Rat
Content                     0.3 mg/ml
Host species               Rabbit
Ig class                  Immunogen-specific rabbit IgG
Purification                 Antigen affinity purification

Target information
Symbol                 ZNF143
Full name                 zinc finger protein 143
Synonyms    SBF; STAF; pHZ-1
Swissprot    P52747

Target Background
ZNF143 (zinc finger protein 143), also known as SBF, STAF or pHZ-1, is a 626 amino acid protein that contains seven C2H2-type zinc fingers and belongs to the GLI (glioma-associated oncogene) C2H2-type zinc-finger family. Localized to the nucleus and expressed ubiquitously with highest expression in ovaries, ZNF143 functions as a transcriptional activator that, via its C2H2-type zinc domains, binds to the SPH motif found in the promotors of small nuclear RNAs (snRNA). Through its ability to bind the promotors of various snRNA genes, ZNF143 controls the subsequent expression of the corresponding protein products. ZNF143 expression is induced upon DNA damage, suggesting an important role for ZNF143 in DNA repair events.