Product overview
Description Anti-PAPPA-AS1 rabbit polyclonal antibody
Applications ELISA, IHC
Immunogen Synthetic peptide of human PAPPA-AS1
Reactivity Human
Content 0.3 mg/ml
Host species Rabbit
Ig class Immunogen-specific rabbit IgG
Purification Antigen affinity purification
Target information
Symbol PAPPA-AS1
Full name PAPPA antisense RNA 1
Synonyms DIPAS; TAF4B; PAPPAS; TAF2C2; PAPPAAS; PAPPA-AS; TAFII105; NCRNA00156
Swissprot Q5QFB9
Target Background
PAPP A was originally isolated from pregnancy serum as heterotetrameric protein complex with molecular weight approximately 500 kDa, consisting of two PAPP A subunits disulfide-linked with two subunits of the proform of eosinophil major basic protein (proMBP). In such a complex proMBP functions as an inhibitor of PAPP A proteinase activity. PAPP A is widely used as a marker of some pathologies during pregnancy. Reduced level of PAPP A in pregnancy blood in the first trimester is associated with fetal Down syndrome. PAPP A is considered as one of the best biochemical markers in early pregnancy used to screen for Down syndrome during the first trimester (Wald, N. J. et al).