Product overview
Description Anti-HAND1 rabbit polyclonal antibody
Applications ELISA, IHC
Immunogen Synthetic peptide of human HAND1
Reactivity Human, Mouse, Rat
Content 0.6 mg/ml
Host species Rabbit
Ig class Immunogen-specific rabbit IgG
Purification Antigen affinity purification
Target information
Symbol HAND1
Full name heart and neural crest derivatives expressed 1
Synonyms Hxt; eHand; Thing1; bHLHa27
Swissprot O96004
Target Background
The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, it has been suggested that this transcription factor may be required for early trophoblast differentiation.