Anti-IRF4 antibody

Anti-IRF4 antibody

Cat. No.     JC220874
Package    25 μl/100 μl/200 μl
Storage    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Product overview
Description                   Anti-IRF4 rabbit polyclonal antibody
Applications        ELISA, IHC 
Immunogen               Fusion protein of human IRF4
Reactivity                 Human, Mouse
Content                     0.2 mg/ml
Host species               Rabbit
Ig class                  Immunogen-specific rabbit IgG
Purification                 Antigen affinity purification

Target information
Symbol                 IRF4
Full name                 interferon regulatory factor 4
Synonyms    MUM1; LSIRF; SHEP8; NF-EM5
Swissprot    Q15306

Target Background
The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene.

Applications
Immunohistochemistry
Predicted cell location: Nucleus
Positive control: Human brain
Recommended dilution: 30-150    Predicted cell location: Nucleus
Positive control: Human lung cancer
Recommended dilution: 30-150