Product overview
Description Anti-APC rabbit polyclonal antibody
Applications ELISA, IHC
Immunogen Synthetic peptide of human APC
Reactivity Human, Mouse, Rat
Content 0.6 mg/ml
Host species Rabbit
Ig class Immunogen-specific rabbit IgG
Purification Antigen affinity purification
Anti-APC antibody Target information
Symbol APC
Full name adenomatous polyposis coli
Synonyms GS; DP2; DP3; BTPS2; DP2.5; PPP1R46
Swissprot P25054
Target Background
This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.
Anti-APC antibody Applications
Immunohistochemistry
Predicted cell location: Cytoplasm
Positive control: Human brain
Recommended dilution: 25-100 Predicted cell location: Cytoplasm
Positive control: Human gastric cancer
Recommended dilution: 25-100