Anti-MOB1B antibody

Anti-MOB1B antibody

Cat. No.     JC160913     
Package    25 μl/100 μl/200 μl
Storage    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Product overview
Description                   Anti-MOB1B rabbit polyclonal antibody
Applications        ELISA, WB 
Immunogen               Synthetic peptide of human MOB1B
Reactivity                 Human, Mouse
Content                     0.1 mg/ml
Host species               Rabbit
Ig class                  Immunogen-specific rabbit IgG
Purification                 Antigen affinity purification

Anti-MOB1B antibody
Target information
Symbol                 MOB1B
Full name                 MOB kinase activator 1B
Synonyms    MATS2; MOB4A; MOBKL1A
Swissprot    Q7L9L4

Target Background
The protein encoded by this gene is similar to the yeast Mob1 protein. Yeast Mob1 binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. Three transcript variants encoding different isoforms have been found for this gene. Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ.

Anti-MOB1B antibody
Applications
Western blotting
Predicted band size:25 kDa
Positive control:Jurkat and K562 cells, mouse testis tissue 
Recommended dilution: 200-1000