Product overview
Description Anti-KCNN3 rabbit polyclonal antibody
Applications ELISA, IHC
Immunogen Synthetic peptide of human KCNN3
Reactivity Human, Mouse, Rat
Content 1.8 mg/ml
Host species Rabbit
Ig class Immunogen-specific rabbit IgG
Purification Antigen affinity purification
Target information
Symbol KCNN3
Full name potassium calcium-activated channel subfamily N member 3
Synonyms SK3; hSK3; SKCA3; KCa2.3
Swissprot Q9UGI6
Target Background
Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. This gene belongs to the KCNN family of potassium channels. It encodes an integral membrane protein that forms a voltage-independent calcium-activated channel, which is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene contains two CAG repeat regions in the coding sequence. It was thought that expansion of one or both of these repeats could lead to an increased susceptibility to schizophrenia or bipolar disorder, but studies indicate that this is probably not the case. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Applications
Immunohistochemistry
Predicted cell location: Cytoplasm
Positive control: Human liver cancer
Recommended dilution: 50-300 Predicted cell location: Cytoplasm
Positive control: Human tonsil
Recommended dilution: 50-300
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using ml264333(KCNN3 Antibody) at dilution 1/60, on the right is treated with synthetic peptide. (Original magnification: ×200) The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using ml264333(KCNN3 Antibody) at dilution 1/60, on the right is treated with synthetic peptide. (Original magnification: ×200)