Anti-ABCB11 antibody

Anti-ABCB11 antibody

Cat. No.  JC160801     
Package    25 μl/100 μl/200 μl
Storage    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Product overview
Description                   Anti-ABCB11 rabbit polyclonal antibody
Applications        ELISA, IHC 
Immunogen               Synthetic peptide of human ABCB11
Reactivity                 Human, Mouse, Rat
Content                     0.2 mg/ml
Host species               Rabbit
Ig class                  Immunogen-specific rabbit IgG
Purification                 Antigen affinity purification

Anti-ABCB11 antibody
Target information
Symbol                 ABCB11
Full name                 ATP-binding cassette, sub-family B (MDR/TAP), member 11
Synonyms    BSEP; PGY4; SPGP; ABC16; BRIC2; PFIC2; PFIC-2
Swissprot    O95342

Target Background
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is the major canalicular bile salt export pump in man. Mutations in this gene cause a form of progressive familial intrahepatic cholestases which are a group of inherited disorders with severe cholestatic liver disease from early infancy.

Anti-ABCB11 antibody
Applications
Immunohistochemistry
Predicted cell location: Cytoplasm
Positive control: Human liver cancer
Recommended dilution: 25-100    Predicted cell location: Cytoplasm
Positive control: Human ovarian cancer
Recommended dilution: 25-100