Anti-EVI2B antibody

Anti-EVI2B antibody

Cat. No.     JC263839
Package    25 μl/100 μl/200 μl
Storage    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Product overview
Description                   Anti-EVI2B rabbit polyclonal antibody
Applications        ELISA, IHC 
Immunogen               Synthetic peptide of human EVI2B
Reactivity                 Human, Mouse
Content                     1.14 mg/ml
Host species               Rabbit
Ig class                  Immunogen-specific rabbit IgG
Purification                 Antigen affinity purification

Target information
Symbol                 EVI2B
Full name                 ecotropic viral integration site 2B
Synonyms    EVDB; CD361; D17S376
Swissprot    P34910

Target Background
EVI2B, also known as CD361. CD361 is a poorly characterized type I transmembrane protein, expressed from one of three genes embedded in intron 27b of the neurofibromatosis type 1 (NF1) gene. The DNA strand that is transcribed to produce CD361 is the complementary one to the strand encoding NF1. Murine homolog to human CD361 is associated with ecotropic viral insertions, which have been implicated in the expression of murine myeloid leukemias. CD361 has been also reported to be involved in melanocyte and keratinocyte differentiation. However, it is expressed mainly in peripheral blood and bone marrow.

Applications
Immunohistochemistry
Predicted cell location: Cytoplasm and Cell membrane
Positive control: Human esophagus cancer
Recommended dilution: 40-200    Predicted cell location: Cytoplasm and Cell membrane
Positive control: Human thyroid cancer
Recommended dilution: 40-200
            
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using ml263839(EVI2B Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)    The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using ml263839(EVI2B Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)

ELISA
Recommended dilution: 5000-10000