Anti-RNF19A antibody

Anti-RNF19A antibody

Cat. No.     JC263736
Package    25 μl/100 μl/200 μl
Storage    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Product overview
Description                   Anti-RNF19A rabbit polyclonal antibody
Applications        ELISA, IHC 
Immunogen               Synthetic peptide of human RNF19A
Reactivity                 Human, Mouse
Content                     0.96 mg/ml
Host species               Rabbit
Ig class                  Immunogen-specific rabbit IgG
Purification                 Antigen affinity purification

Target information
Symbol                 RNF19A
Full name                 ring finger protein 19A, RBR E3 ubiquitin protein ligase
Synonyms    RNF19
Swissprot    Q9NV58

Target Background
This gene encodes a member of the ring between ring fingers (RBR) protein family, and the encoded protein contains two RING-finger motifs and an in between RING fingers motif. This protein is an E3 ubiquitin ligase that is localized to Lewy bodies, and ubiquitylates synphilin-1, which is an interacting protein of alpha synuclein in neurons. The encoded protein may be involved in amyotrophic lateral sclerosis and Parkinson's disease. Alternative splicing results in multiple transcript variants.

Applications
Immunohistochemistry
Predicted cell location: Cytoplasm
Positive control: Human liver cancer
Recommended dilution: 25-100    Predicted cell location: Cytoplasm
Positive control: Human lung cancer
Recommended dilution: 25-100
            
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using ml263736(RNF19A Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200)    The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using ml263736(RNF19A Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200)

ELISA
Recommended dilution: 5000-10000