Anti-MEN1 antibody

Anti-MEN1 antibody

Cat. No.     JC262984
Package    25 μl/100 μl/200 μl
Storage    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Product overview
Description                   Anti-MEN1 rabbit polyclonal antibody
Applications        ELISA, WB, IHC 
Immunogen               Synthetic peptide of human MEN1
Reactivity                 Human, Mouse, Rat
Content                     0.1 mg/ml
Host species               Rabbit
Ig class                  Immunogen-specific rabbit IgG
Purification                 Antigen affinity purification

Target information
Symbol                 MEN1
Full name                 multiple endocrine neoplasia I
Synonyms    MEAI; SCG2
Swissprot    O00255

Target Background
This gene encodes menin, a putative tumor suppressor associated with a syndrome known as multiple endocrine neoplasia type 1. In vitro studies have shown menin is localized to the nucleus, possesses two functional nuclear localization signals, and inhibits transcriptional activation by JunD, however, the function of this protein is not known. Two messages have been detected on northern blots but the larger message has not been characterized. Alternative splicing results in multiple transcript variants.

Applications
Immunohistochemistry
Predicted cell location: Cytoplasm
Positive control: Human tonsil
Recommended dilution: 25-100    
            
The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using ml262984(MEN1 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)    
Western blotting
Predicted band size:68 kDa
Positive control:Raji and Jurkat cell 
Recommended dilution: 500-2000