Product overview
Description Anti-DOK7 rabbit polyclonal antibody
Applications ELISA, IHC
Immunogen Synthetic peptide of human DOK7
Reactivity Human, Mouse
Content 0.7 mg/ml
Host species Rabbit
Ig class Immunogen-specific rabbit IgG
Purification Antigen affinity purification
Target information
Symbol DOK7
Full name docking protein 7
Synonyms CMS10; CMS1B; C4orf25
Swissprot Q18PE1
Target Background
The protein encoded by this gene is essential for neuromuscular synaptogenesis. The protein functions in aneural activation of muscle-specific receptor kinase, which is required for postsynaptic differentiation, and in the subsequent clustering of the acetylcholine receptor in myotubes. This protein can also induce autophosphorylation of muscle-specific receptor kinase. Mutations in this gene are a cause of familial limb-girdle myasthenia autosomal recessive, which is also known as congenital myasthenic syndrome type 1B. Alternative splicing results in multiple transcript variants.
Applications
Immunohistochemistry
Predicted cell location: Cytoplasm
Positive control: Human liver cancer
Recommended dilution: 25-100
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using ml262868(DOK7 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: ×200)