Product overview Description Anti-FEM1A rabbit polyclonal antibody
Applications ELISA, IHC
Immunogen Synthetic peptide of human FEM1A
Reactivity Human
Content 0.7 mg/ml
Host species Rabbit
Ig class Immunogen-specific rabbit IgG
Purification Antigen affinity purification
Target information Symbol FEM1A
Full name fem-1 homolog a (C. elegans)
Synonyms EPRAP
Swissprot Q9BSK4
Target Background FEM1A (FEM-1 homolog a), also known as EPRAP (Prostaglandin E receptor 4-associated protein), is a 669 amino acid cytoplasmic protein that belongs to the FEM-1 family. FEM1A is present in atheromata and in macrophages derived from peripheral blood monocytes. FEM1A may be a component of an E3 ubiquitin-protein ligase complex and functions as a substrate recognition subunit. It is suggested that FEM1A participates in anti-inflammatory signaling of macrophages via its interaction with EP4. FEM1A is down-regulated in Rhabdomyosarcoma, the most common soft tissue neoplasm of children. FEM1A is considered a candidate gene for polycystic ovary syndrome.