Product overview Description Anti-CDC14B rabbit polyclonal antibody
Applications ELISA, IHC
Immunogen Synthetic peptide of human CDC14B
Reactivity Human
Content 0.5 mg/ml
Host species Rabbit
Ig class Immunogen-specific rabbit IgG
Purification Antigen affinity purification
Target information Symbol CDC14B
Full name cell division cycle 14B
Synonyms CDC14B3; Cdc14B1; Cdc14B2; hCDC14B
Swissprot O60729
Target Background The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. This protein is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, which suggests the role in cell cycle control. This protein has been shown to interact with and dephosphorylates tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splice of this gene results in 3 transcript variants encoding distinct isoforms.