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- 详细信息
- 文献和实验
- 技术资料
- 库存:
详询
- 供应商:
南京莱富赛
- 检测方法:
Competitive ELISA
- 应用:
ELISA
- 适应物种:
Human (Homo sapiens)
- 样本:
参考说明书
- 规格:
96T
Application Details:Detect Range:Detection antibody
Sensitivity:Request Information
Sample Type:Serum, Plasma, Other biological fluids
Sample Volume: 1-200 uL
Assay Time:1-4.5h
Detection wavelength:450 nm
产品详细信息请点击:Human Dengue fever IgM antibody (DF-Ab-IgM) ELISA Kit
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文献和实验Global incidence of dengue has increased considerably over the past decade. Dengue fever (DF) is a self-limiting disease; however, dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS) are fatal. Since there is no therapy and vaccine
consists of a cooperation between monocytes and cytophilic antibodies able to bind to the Fc receptors present on the monocyte surface. Thus human IgG1 and IgG3 are the main isotypes effective in ADCI, whereas IgG2, IgG4, and IgM are ineffective
部位IgG可被胃蛋白酶分解为两个片段,一个Fab双体,称F(ab')2,能和两个相同的抗原结合;另一片段类似Fc,随后被分解成小分子多肽,无生物活性。IgM是由五个单体组成的五聚体,含10个重链和10个轻链,具有10个抗原结合价,由于空间位置的影响,只表现为五个抗原结合价。IgM分子量约为900000,IgG分子量约为150000.机体被微生物感染后,先产生IgM抗体,然后产生IgG抗体。经过一段时间,IgM抗体量逐渐减少而消失,而IgG抗体可长期存在,在疾病痊愈后可持续数年之久。IgM抗体
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