Anti-HNRNPM antibody

Anti-HNRNPM antibody

Cat. No.     JC262507
Package    25 μl/100 μl/200 μl
Storage    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Product overview
Description                   Anti-HNRNPM rabbit polyclonal antibody
Applications        ELISA, WB, IHC 
Immunogen               Synthetic peptide of human HNRNPM
Reactivity                 Human, Mouse, Rat
Content                     0.2 mg/ml
Host species               Rabbit
Ig class                  Immunogen-specific rabbit IgG
Purification                 Antigen affinity purification

Target information
Symbol                 HNRNPM
Full name                 heterogeneous nuclear ribonucleoprotein M
Synonyms    CEAR; HNRPM; HTGR1; NAGR1; HNRPM4; HNRNPM4; hnRNP M
Swissprot    P52272

Target Background
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNAs. This protein also constitutes a monomer of the N-acetylglucosamine-specific receptor which is postulated to trigger selective recycling of immature GlcNAc-bearing thyroglobulin molecules. Alternative splicing results in multiple transcript variants.

Applications
Immunohistochemistry
Predicted cell location: Nucleus
Positive control: Human breast cancer
Recommended dilution: 25-100    Predicted cell location: Nucleus
Positive control: Human liver cancer
Recommended dilution: 25-100
            
The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using ml262507(HNRNPM Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200)    The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using ml262507(HNRNPM Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200)
Western blotting
Predicted band size:78 kDa
Positive control:HT-29, A172, hela and 293T cell 
Recommended dilution: 500-2000