- 询价
- Signalway Antibody
- USA
- AP79367
- 2025年07月10日
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- 详细信息
- 技术资料
- 保存条件：
Store at -20˚C
- 英文名：
R-spondin-1
- 库存：
详询
- 供应商：
南京莱富赛
- 规格：
详询
host_species:E.coli
purification:>90% by SDS-PAGE
specificity:Human
other_names:Roof plate-specific spondin-1,hRspo1
accession_no:Q2MKA7
Gene name:RSPO1
calculated_mw:
tag info:His
Immunogen Description:Recombinant protein
formulation:50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole,10%glycerol(PH8.0)
storage:Store at -20C. (Avoid repeated freezing and thawing.)
Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
background:Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination.
产品详细信息请点击：R-spondin-1
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