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- Signalway Antibody
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- AP78156
- 2025年07月06日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Store at -20˚C
- 英文名：
Recombinant Human Atypical chemokine receptor 3(ACKR3)
- 库存：
详询
- 供应商：
南京莱富赛
- 规格：
详询
host_species:in vitro E.coli expression system
purification:Greater than 90% as determined by SDS-PAGE.
other_names:C-X-C chemokine receptor type 7 Short name: CXC-R7 Short name: CXCR-7 Chemokine orphan receptor 1 G-protein coupled receptor 159 G-protein coupled receptor RDC1 homolog Short name: RDC-1
accession_no:P25106
calculated_mw:57.5 kDa
tag info:N-terminal 6xHis-SUMO-tagged
Immunogen Description:Expression Region:1-362aa
Sequence Info:Full Length
formulation:Tris-based buffer50% glycerol
storage:The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20℃,-80℃. The shelf life of lyophilized form is 12 months at -20℃,-80℃.
Notes:Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
background:Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CXCL11 and CXCL12,SDF1. Chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization and activation of MAPK signaling pathway. Required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness. In glioma cells, transduces signals via MEK,ERK pathway, mediating resistance to apoptosis. Promotes cell growth and survival. Not involved in cell migration, adhesion or proliferation of normal hematopoietic progenitors but activated by CXCL11 in malignant hemapoietic cells, leading to phosphorylation of ERK1,2 (MAPK3,MAPK1) and enhanced cell adhesion and migration. Plays a regulatory role in CXCR4-mediated activation of cell surface integrins by CXCL12. Required for heart valve development. Acts as coreceptor with CXCR4 for a restricted number of HIV isolates.
产品详细信息请点击：Recombinant Human Atypical chemokine receptor 3(ACKR3)
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文献和实验Analysis of CXCR3 and Atypical Variant Expression and Signalling in Human T Lymphocytes
Members of the chemokine (Chemo tactic cytokines ) superfamily and their receptors play a major role in trafficking of immune cells under homeostatic and inflammatory conditions. The chemokine receptor CXCR3 is expressed mainly on activated T
Characterization of Chemokine Receptors
Confluent cells expressing a recombinant chemokine receptor (e.g., CHO, HEK) grown in 75‐ml flasks in appropriate growth medium PBS (unit 12.4 ) with and without 1 mM
Overview of Receptor Allosterism
), a potent, orally bioavailable, and selective small‐molecule inhibitor of chemokine receptor CCR5 with broad‐spectrum anti‐human immunodeficiency virus type 1 activity. Antimicrob. Agents Chemother. 49:4721‐4732.
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