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- Signalway Antibody
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- AP77730
- 2025年07月11日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Store at -20˚C
- 英文名：
Recombinant Human Von Hippel-Lindau disease tumor suppressor(VHL)
- 库存：
详询
- 供应商：
南京莱富赛
- 规格：
详询
host_species:E.coli
purification:Greater than 85% as determined by SDS-PAGE.
other_names:Protein G7 pVHL
accession_no:P40337
calculated_mw:28.2 kDa
tag info:N-terminal 6xHis-tagged
Immunogen Description:Expression Region:1-213aa
Sequence Info:Full Length
formulation:Tris-based buffer50% glycerol
storage:The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20℃,-80℃. The shelf life of lyophilized form is 12 months at -20℃,-80℃.
Notes:Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
background:Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases. Ubiquitinates, in an oxygen-responsive manner, ADRB2.
产品详细信息请点击：Recombinant Human Von Hippel-Lindau disease tumor suppressor(VHL)
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文献和实验Molecular Analysis of the von Hippel-Lindau Disease Gene
Von Hippel-Lindau (VHL) disease is an autosomal dominant disorder that predisposes the affected individual to develop characteristic tumors. These include CNS hemangioblastoma, retinal angiomas, endolymphatic sac tumors, pancreatic cysts
kidney cancer that have been categorized: renal carcinoma associated with Birt-Hogg-Dube syndrome, hereditary papillary renal carcinoma, hereditary clear cell renal carcinoma, and renal carcinoma associated with the von Hippel-Lindau (VHL) disease
Microarray Approaches for Analysis of Tumor Suppressor Gene Function
TP53 Tumor protein p53 WT1 Wilm’s tumor 1 VHL Von Hippel-Lindau syndrome
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