- 询价
- Signalway Antibody
- USA
- AP77615
- 2025年07月09日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Store at -20˚C
- 英文名：
Recombinant Pig Interleukin-4 receptor subunit alpha(IL4R),Partial
- 库存：
详询
- 供应商：
南京莱富赛
- 规格：
详询
host_species:E.coli
purification:Greater than 85% as determined by SDS-PAGE.
other_names:CD_antigen: CD124
accession_no:Q863Z5
calculated_mw:28.2 kDa
tag info:N-terminal 6xHis-tagged
Immunogen Description:Expression Region:33-240aa
Sequence Info:Extracellular Domain
formulation:Tris-based buffer50% glycerol
storage:The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20℃,-80℃. The shelf life of lyophilized form is 12 months at -20℃,-80℃.
Notes:Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
background:Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1,2,3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4,IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1,IRS2
产品详细信息请点击：Recombinant Pig Interleukin-4 receptor subunit alpha(IL4R),Partial
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文献和实验Overview of Receptor Allosterism
mechanism of G protein‐coupled receptor functional selectivity. Muscarinic partial agonist McN‐A‐343 as a bitopic orthosteric/allosteric ligand. J. Biol. Chem. 283:29312‐29321.
such as neuronal differentiation and bone loss. To produce these effects IL-6 signals through a receptor composed of two different subunits, an alpha subunit that produces ligand specificity and gp130, a receptor subunit shared in common with other cytokines
-2R (IL-2 Receptor) alpha subunit primarily increases the affinity of ligand binding and is not known to contain a signaling domain, whereas the beta and gamma subunits participate in both ligand binding and signal transduction (Ref.1). The IL-2R signaling
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