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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Store at -20˚C
- 英文名：
Recombinant Mouse 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial(Cyp27b1)
- 库存：
详询
- 供应商：
南京莱富赛
- 规格：
详询
host_species:E.coli
purification:Greater than 90% as determined by SDS-PAGE.
other_names:25-OHD-1 alpha-hydroxylase 25-hydroxyvitamin D(3) 1-alpha-hydroxylase
accession_no:O35084
calculated_mw:60.2 kDa
tag info:N-terminal 6xHis-tagged
Immunogen Description:Expression Region:1-507aa
Sequence Info:Full Length
formulation:Tris-based buffer50% glycerol
storage:The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20℃,-80℃. The shelf life of lyophilized form is 12 months at -20℃,-80℃.
Notes:Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
background:Catalyzes the conversion of 25-hydroxyvitamin D3 (25(OH)D3) to 1-alpha,25-dihydroxyvitamin D3 (1alpha,25(OH)2D3), and of 24,25-dihydroxyvitamin D3 (24,25(OH)2D3) to 1-alpha,24,25-trihydroxyvitamin D3 (1alpha,24,25(OH)3D3). Is also active with 25-hydroxy-24-oxo-vitamin D3. Plays an important role in normal bone growth, calcium metabolism, and tissue differentiation.
产品详细信息请点击：Recombinant Mouse 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial(Cyp27b1)
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文献和实验In situ hybridisation to alpha satellite sequences (chromosome specific)
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Mouse Strains and Genetic Nomenclature
. We also provide some guidance to make the best possible choice when establishing an experimental protocol. Curr. Protoc. Mouse Biol. 1:213?238. © 2011 by John Wiley & Sons, Inc. Keywords: inbred strains; congenic strains; recombinant inbred
ITGA4（CD49D）信号通路、病理作用与靶向治疗药物研究梳理
整合素alpha 4（ITGA4），又称CD49D，是整合素家族的关键亚基。它通过与β1或β7亚基结合，形成功能性异二聚体α4β1（VLA-4）和α4β7，在免疫细胞的黏附、运输及迁移中扮演核心角色。VLA-4还能介导白细胞在活化内皮细胞上的聚集。鉴于ITGA4在多发性硬化、炎症性肠病等多种自身免疫性疾病的病理过程中发挥关键作用，它已成为治疗干预的重要靶点。 ITGA4的表达分布 ITGA4主要分布于巨核细胞、红细胞、干细胞、NK细胞以及T细胞中。在T细胞亚群中，CD49D主要在CD
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