Product overview
Description Anti-GCG(GLP2) rabbit polyclonal antibody
Applications ELISA, IHC
Immunogen Synthetic peptide of human GCG(GLP2)
Reactivity Human, Mouse, Rat
Content 0.4 mg/ml
Host species Rabbit
Ig class Immunogen-specific rabbit IgG
Purification Antigen affinity purification
Target information
Symbol GCG
Full name glucagon
Synonyms GLP1; GLP2; GRPP
Swissprot P01275
Target Background
The protein encoded by this gene is actually a preproprotein that is cleaved into four distinct mature peptides. One of these, glucagon, is a pancreatic hormone that counteracts the glucose-lowering action of insulin by stimulating glycogenolysis and gluconeogenesis. Glucagon is a ligand for a specific G-protein linked receptor whose signalling pathway controls cell proliferation. Two of the other peptides are secreted from gut endocrine cells and promote nutrient absorption through distinct mechanisms. Finally, the fourth peptide is similar to glicentin, an active enteroglucagon.
Applications
Immunohistochemistry
Predicted cell location: Cytoplasm
Positive control: Human gasrtic cancer
Recommended dilution: 50-200 Predicted cell location: Cytoplasm
Positive control: Human thyroid cancer
Recommended dilution: 50-200
The image on the left is immunohistochemistry of paraffin-embedded Human gasrtic cancer tissue using ml261668(GCG(GLP2) Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200) The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using ml261668(GCG(GLP2) Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)