Anti-ABCA4 antibody

Anti-ABCA4 antibody

Cat. No.     JC261218   
Package    25 μl/100 μl/200 μl
Storage    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Product overview
Description                   Anti-ABCA4 rabbit polyclonal antibody
Applications        ELISA, IHC 
Immunogen               Synthetic peptide of human ABCA4
Reactivity                 Human
Content                     0.2 mg/ml
Host species               Rabbit
Ig class                  Immunogen-specific rabbit IgG
Purification                 Antigen affinity purification

Target information
Symbol                 ABCA4
Full name                 ATP-binding cassette, sub-family A (ABC1), member 4
Synonyms    FFM; RMP; ABCR; RP19; STGD; ABC10; ARMD2; CORD3; STGD1
Swissprot    P78363

Target Background
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This protein is a retina-specific ABC transporter with N-retinylidene-PE as a substrate. It is expressed exclusively in retina photoreceptor cells, indicating the gene product mediates transport of an essental molecule across the photoreceptor cell membrane. Mutations in this gene are found in patients diagnosed with Stargardt disease, a form of juvenile-onset macular degeneration. Mutations in this gene are also associated with retinitis pigmentosa-19, cone-rod dystrophy type 3, early-onset severe retinal dystrophy, fundus flavimaculatus, and macular degeneration age-related 2.

Applications
Immunohistochemistry
Predicted cell location: Membrane, Cytoplasm
Positive control: Human cervical cancer
Recommended dilution: 50-200    Predicted cell location: Membrane, Cytoplasm
Positive control: Human thyroid cancer
Recommended dilution: 50-200
            
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using ml261218(ABCA4 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200)    The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using ml261218(ABCA4 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200)

ELISA
Recommended dilution: 2000-5000