Anti-DNASE1 antibody

Anti-DNASE1 antibody

Cat. No.     JC122246        
Package    25 μl/100 μl/200 μl
Storage    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Product overview
Description                   Anti-DNASE1 rabbit polyclonal antibody
Applications        ELISA, IHC 
Immunogen               Fusion protein of human DNASE1
Reactivity                 Human, Mouse, Rat
Content                     0.2 mg/ml
Host species               Rabbit
Ig class                  Immunogen-specific rabbit IgG
Purification                 Antigen affinity purification

Anti-DNASE1 antibody
Target information
Symbol                 DNASE1
Full name                 deoxyribonuclease I
Synonyms    DNL1; DRNI
Swissprot    P24855

Target Background
This gene encodes a member of the DNase family. This protein is stored in the zymogen granules of the nuclear envelope and functions by cleaving DNA in an endonucleolytic manner. At least six autosomal codominant alleles have been characterized, DNASE1*1 through DNASE1*6, and the sequence of DNASE1*2 represented in this record. Mutations in this gene have been associated with systemic lupus erythematosus (SLE), an autoimmune disease. A recombinant form of this protein is used to treat the one of the symptoms of cystic fibrosis by hydrolyzing the extracellular DNA in sputum and reducing its viscosity. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.

Anti-DNASE1 antibody
Applications
Immunohistochemistry
Predicted cell location: Secreted
Positive control: Human thyroid cancer
Recommended dilution: 25-100