Product overview
Description Anti-CYP17A1 rabbit polyclonal antibody
Applications ELISA, IHC
Immunogen Fusion protein of human CYP17A1
Reactivity Human
Content 0.7 mg/ml
Host species Rabbit
Ig class Immunogen-specific rabbit IgG
Purification Antigen affinity purification
Anti-CYP17A1 antibody Target information
Symbol CYP17A1
Full name cytochrome P450, family 17, subfamily A, polypeptide 1
Synonyms CPT7; CYP17; S17AH; P450C17
Swissprot P05093
Target Background
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. It has both 17alpha-hydroxylase and 17,20-lyase activities and is a key enzyme in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens. Mutations in this gene are associated with isolated steroid-17 alpha-hydroxylase deficiency, 17-alpha-hydroxylase/17,20-lyase deficiency, pseudohermaphroditism, and adrenal hyperplasia.
Anti-CYP17A1 antibody Applications
Immunohistochemistry
Predicted cell location: Cytoplasm
Positive control: Human liver cancer
Recommended dilution: 50-200 Predicted cell location: Cytoplasm
Positive control: Human gastric cancer
Recommended dilution: 50-200