Anti-CPSF4 antibody

Anti-CPSF4 antibody

Cat. No.     JC122145        
Package    25 μl/100 μl/200 μl
Storage    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Product overview
Description                   Anti-CPSF4 rabbit polyclonal antibody
Applications        ELISA, IHC 
Immunogen               Fusion protein of human CPSF4
Reactivity                 Human, Mouse, Rat
Content                     0.3 mg/ml
Host species               Rabbit
Ig class                  Immunogen-specific rabbit IgG
Purification                 Antigen affinity purification

Anti-CPSF4 antibody
Target information
Symbol                 CPSF4
Full name                 cleavage and polyadenylation specific factor 4, 30kDa
Synonyms    NAR; NEB1; CPSF30
Swissprot    O95639

Target Background
Inhibition of the nuclear export of poly(A)-containing mRNAs caused by the influenza A virus NS1 protein requires its effector domain. The NS1 effector domain functionally interacts with the cellular 30 kDa subunit of cleavage and polyadenylation specific factor 4, an essential component of the 3' end processing machinery of cellular pre-mRNAs. In influenza virus-infected cells, the NS1 protein is physically associated with cleavage and polyadenylation specific factor 4, 30kD subunit. Binding of the NS1 protein to the 30 kDa protein in vitro prevents CPSF binding to the RNA substrate and inhibits 3' end cleavage and polyadenylation of host pre-mRNAs.

Anti-CPSF4 antibody
Applications
Immunohistochemistry
Predicted cell location: Nucleus
Positive control: Human thyroid cancer
Recommended dilution: 25-100    Predicted cell location: Nucleus
Positive control: Human brain
Recommended dilution: 25-100