Anti-CPSF4 Polyclonal Antibody

产品简介

英文名称	Anti-CPSF4 Polyclonal Antibody
宿主	Rabbit
别名	CPSF4;CPSF30;NAR;NEB-1;NEB1;cleavage and polyadenylation specific factor 4
稀释比例	IHC 1:25-100.
蛋白分子量	27/30kDa
Gene ID	10898
保存	Store at -20°C. Avoid freeze / thaw cycles.
储存液	Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
纯化方法	Affinity purification
亚型	IgG
免疫原	Recombinant protein of human CPSF4
亚细胞定位	Nucleus Cytoplasm
Swiss Prot	O95639
背景资料	Inhibition of the nuclear export of poly(A)-containing mRNAs caused by the influenza A virus NS1 protein requires its effector domain. The NS1 effector domain functionally interacts with the cellular 30 kDa subunit of cleavage and polyadenylation specific factor 4, an essential component of the 3' end processing machinery of cellular pre-mRNAs. In influenza virus-infected cells, the NS1 protein is physically associated with cleavage and polyadenylation specific factor 4, 30kD subunit. Binding of the NS1 protein to the 30 kDa protein in vitro prevents CPSF binding to the RNA substrate and inhibits 3' end cleavage and polyadenylation of host pre-mRNAs. Thus the NS1 protein selectively inhibits the nuclear export of cellular, and not viral, mRNAs. Multiple alternatively spliced transcript variants that encode different isoforms have been described for this gene.
Public Immunogen Range	1-269aa
克隆类型	Polyclonal Antibody
交叉反应	Human Rat Mouse
应用	IHC
规格	50ul 100ul

备注：
以上数据均来自公开文献, Solarbio暂未进行独立验证, 仅供参考。
These protocols are for reference only. Solarbio does not independently validate these methods.
实验图