Product overview
Description Anti-ACLY rabbit polyclonal antibody
Applications ELISA, IHC
Immunogen Fusion protein of human ACLY
Reactivity Human, Mouse, Rat
Content 0.4 mg/ml
Host species Rabbit
Ig class Immunogen-specific rabbit IgG
Purification Antigen affinity purification
Anti-ACLY antibody Target information
Symbol ACLY
Full name ATP citrate lyase
Synonyms ACL; ATPCL; CLATP
Swissprot P53396
Target Background
ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Two transcript variants encoding distinct isoforms have been identified for this gene.
Anti-ACLY antibody Applications
Immunohistochemistry
Predicted cell location: Nucleus and Cytoplasm
Positive control: Human liver cancer
Recommended dilution: 50-200 Predicted cell location: Nucleus and Cytoplasm
Positive control: Human brain
Recommended dilution: 50-200