FITC标记的肌动蛋白解聚因子抗体

FITC标记的肌动蛋白解聚因子抗体

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  • ¥2980
  • LMAI Bio
  • LM-12997R-FITC
  • 中国/美国/欧洲
  • 2025年07月10日
  • ICC=1:50-200 IF=1:50-200
  • Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Monkey,
  • Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Monkey,
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    • 详细信息
    • 技术资料
    • 供应商

      上海联迈生物工程有限公司

    • 库存

      大量

    • 靶点

      详见说明书

    • 级别

      1

    • 目录编号

      LM-12997R-FITC

    • 克隆性

      多克隆

    • 抗原来源

      Rabbit

    • 保质期

      1年

    • 抗体英文名

      Anti-Destrin/FITC

    • 抗体名

      Anti-Destrin/FITC

    • 标记物

      FITC标记

    • 宿主

      Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Monkey,

    • 适应物种

      Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Monkey,

    • 免疫原

      详见说明书

    • 亚型

      IGg

    • 形态

      粉末、液体、冻干粉

    • 应用范围

      ICC=1:50-200 IF=1:50-200

    • 浓度

      1mg/ml

    • 保存条件

      -20 °C

    • 规格

      100ul

    FITC标记的肌动蛋白解聚因子抗体
    英文名称 Anti-Destrin/FITC
    中文名称 FITC标记的肌动蛋白解聚因子抗体
    别    名 2610043P17Rik; ACTDP; Actin depolymerizing factor; Actin-depolymerizing factor; ADF; AU042046; bA462D18.2; corn1; DEST_HUMAN; Destrin (actin depolymerizing factor); Destrin; DSN; Dstn; Sid 23; sid23p.  
    规格价格 100ul/2980元 购买        大包装/询价
    说 明 书 100ul  
    研究领域 细胞生物  信号转导  结合蛋白  细胞骨架  
    抗体来源 Rabbit
    克隆类型 Polyclonal
    交叉反应 Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Monkey, 
    产品应用 ICC=1:50-200 IF=1:50-200  
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量 19kDa
    性    状 Lyophilized or Liquid
    浓    度 1mg/ml
    免 疫 原 KLH conjugated synthetic peptide derived from human Destrin
    亚    型 IgG
    纯化方法 affinity purified by Protein A
    储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
    产品介绍 background:
    Actin-depolymerizing factor (ADF), also known as destrin, is a member of the ADF/Cofilin/destrin superfamily that has the ability to rapidly depolymerize F-Actin in a stoichiometric manner. The Actin-depolymerizing activity of ADF is reversibly controlled by changes in KCl concentration but is insensitive to calcium concentration. ADF depolymerizes F-Actin by interacting directly with F-Actin protomers. ADF shares 71% sequence homology with Cofilin, however the two proteins differ in their interaction with Actin. The difference in the function of ADF and Cofilin results from the subtle difference in their amino acid sequence rather than possible differences in posttranslational modifications. As a result of different cleavage sites on ADF and Cofilin, the proteins differ in their overall tertiary folds. Sensitivity to polyphosphoinositides may be a common feature in vitro among Actin-binding proteins such as ADF and Cofilin that can bind to G-Actin and regulate the state of Actin polymerization. ADF and Cofilin are Actin-depolymerizing proteins whose activities are possibly regulated by their phosphorylation/dephosphorylation.

    Function:
    Actin-depolymerizing protein. Severs actin filaments (F-actin) and binds to actin monomers (G-actin). Acts in a pH-independent manner.

    Tissue Specificity:
    Widely distributed in various tissues.

    Post-translational modifications:
    ISGylated.

    Similarity:
    Belongs to the actin-binding proteins ADF family.
    Contains 1 ADF-H domain.

    Database links:
    UniProtKB/Swiss-Prot: P60981.3

    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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