Product overview
Description Anti-ALKBH1 rabbit polyclonal antibody
Applications ELISA, WB
Immunogen Fusion protein of human ALKBH1
Reactivity Human, Mouse
Content 0.3 mg/ml
Host species Rabbit
Ig class Immunogen-specific rabbit IgG
Purification Antigen affinity purification
Anti-ALKBH1 antibody Target information
Symbol ALKBH1
Full name AlkB, alkylation repair homolog 1 (E. coli)
Synonyms ABH; ABH1; alkB; hABH; ALKBH
Swissprot Q13686
Target Background
This gene encodes a homolog to the E. coli alkB gene product. The E. coli alkB protein is part of the adaptive response mechanism of DNA alkylation damage repair. It is involved in damage reversal by oxidative demethylation of 1-methyladenine and 3-methylcytosine. Dioxygenase that repairs alkylated single-stranded DNA and RNA containing 3-methylcytosine by oxidative demethylation. Requires molecular oxygen, alpha-ketoglutarate and iron. May have a role in placental trophoblast lineage differentiation. Has DNA lyase activity and introduces double-stranded breaks at abasic sites. Cleaves both single-stranded DNA and double-stranded DNA at abasic sites, with the greatest activity towards double-stranded DNA with two abasic sites.
Anti-ALKBH1 antibody Applications
Western blotting
Predicted band size:44 kDa
Positive control:Mouse pancreas tissue
Recommended dilution: 500-2000