Anti-KDM2A antibody

Anti-KDM2A antibody

Cat. No.     JK263892        
Package    25 μl/100 μl/200 μl
Storage    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Product overview
Description                   Anti-KDM2A rabbit polyclonal antibody
Applications        ELISA, IHC 
Immunogen               Synthetic peptide of human KDM2A
Reactivity                 Human, Mouse
Content                     1.74 mg/ml
Host species               Rabbit
Ig class                  Immunogen-specific rabbit IgG
Purification                 Antigen affinity purification


Target information
Symbol                 KDM2A
Full name                 lysine demethylase 2A
Synonyms    FBL7; CXXC8; FBL11; FBXL11; JHDM1A; LILINA
Swissprot    Q9Y2K7

Target Background
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains at least six highly degenerated leucine-rich repeats. This family member plays a role in epigenetic silencing. It nucleates at CpG islands and specifically demethylates both mono- and di-methylated lysine-36 of histone H3. Alternative splicing results in multiple transcript variants.