Anti-ANXA7 antibody

Anti-ANXA7 antibody

Cat. No.     JC120067        
Package    25 μl/100 μl/200 μl
Storage    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Product overview
Description                   Anti-ANXA7 rabbit polyclonal antibody
Applications        ELISA, IHC 
Immunogen               Fusion protein of human ANXA7
Reactivity                 Human, Mouse
Content                     0.9 mg/ml
Host species               Rabbit
Ig class                  Immunogen-specific rabbit IgG
Purification                 Antigen affinity purification

Anti-ANXA7 antibody
Target information
Symbol                 ANXA7
Full name                 Annexin A7
Synonyms    SNX, ANX7, SYNEXIN
Swissprot    P20073

Target Background
Annexin VII is a member of the annexin family of calcium-dependent phospholipid binding proteins.The Annexin VII gene contains 14 exons and spans approximately 34 kb of DNA. An alternatively spliced cassette exon results in two mRNA transcripts of 2.0 and 2.4 kb which are predicted to generate two protein isoforms differing in their N-terminal domain. The alternative splicing event is tissue specific and the mRNA containing the cassette exon is prevalent in brain, heart and skeletal muscle. The transcripts also differ in their 3'-non coding regions by the use of two alternative poly(A) signals. Annexin VII encodes a protein with a molecular weight of approximately 51 kDa with a unique, highly hydrophobic N-terminal domain of 167 amino acids and a conserved C-terminal region of 299 amino acids. The latter domain is composed of alternating hydrophobic and hydrophilic segments. Structural analysis of the protein suggests that Annexin VII is a membrane binding protein with diverse properties, including voltage-sensitive calcium channel activity, ion selectivity and membrane fusion.

Anti-ANXA7 antibody
Applications
Immunohistochemistry
Predicted cell location: Cytoplasm, Cell membrane
Positive control: Human lung cancer
Recommended dilution: 50-200    Predicted cell location: Cytoplasm, Cell membrane
Positive control: Human renal cancer
Recommended dilution: 50-200